X-ray and neutron scattering study of organic-organic heterolayers for organic electronics and biointerfaces
نویسنده
چکیده
We develop a bioadhesive coating based on a synthetic peptide-conjugate (AK-cyclo[RGDfC])which contains multiples of the arginyl-glycyl-aspartic acid (RGD) amino acid sequence.Biotinated AK-cyclo[RGDfC] is bound to a supported lipid bilayer via a streptavidin inter-layer. Layering, hydration and packing of the coating is quantified by x-ray and neutronreflectometry experiments. AK-cyclo[RGDfC] binds to the streptavidin interlayer in astretched-out on edge configuration. The highly packed configuration with only 12% wa-ter content maximizes the number of accessible adhesion sites. Enhanced cell spreadingof neural stem cells was observed for AK-cyclo[RGDfC] functionalized bilayers. Due tothe large variety of surfaces which can be coated by physisorption of lipid bilayers, thisapproach is of general interest for the fabrication of biocompatible surfaces.
منابع مشابه
Aggregation of monocarboxylic polymer chains by neutralization. Neutron and X ray scattering
2014 The aggregates obtained by the neutralization of a carboxylic single-ended polymer chain in organic solvent are studied. Neutron and X-ray small angle scattering are used for the characterisation of the aggregates and for the study of their structure as a function of concentration. J. Phys. France 49 (1988) 1775-1783 OCTOBRE 1988, Classification Physics Abstracts 82.70 61.12 61.40
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